Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin

Bioinformatics and In Vitro Studies Reveal the Importance of p53, PPARG and Notch Signaling Pathway in Inhibition of Breast Cancer Stem Cells by Hesperetin

Purpose: The failure of chemotherapy in breast cancer is caused by breast cancer stem cells (BCSCs), a minor population of cells in bulk mammary tumors. Previously, hesperetin, a citrus flavonoid, showed cytotoxicity in several cancer cells and increased cytotoxicity of doxorubicin and cisplatin. He...

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Bibliographic Details
Main Authors: Adam Hermawan, Muthi Ikawati, Annisa Khumaira, Herwandhani Putri, Riris Istighfari Jenie, Sonia Meta Angraini, Haruma Anggraini Muflikhasari
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2021-02-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
hesperetin
breast cancer stem cells
bioinformatics
in vitro
mammosphere
targeted therapy
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-11-351.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-11-351.pdf

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