Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination betw...

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Détails bibliographiques
Auteurs principaux: Ana R. Correia, Subhashchandra Naik, Mark T. Fisher, Cláudio M. Gomes
Format: Article
Langue:English
Publié: MDPI AG 2014-10-01
Collection:Biomolecules
Sujets:
clinical mutants
missense mutants
frataxin
Friedreich’s ataxia
protein folding
chaperonin
osmolytes
protein stability
protein misfolding and misfolding diseases
Accès en ligne:http://www.mdpi.com/2218-273X/4/4/956

Internet

http://www.mdpi.com/2218-273X/4/4/956

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