Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

ABSTRACT Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls mediated via the VSG 3′ untranslated region (UTR). To...

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Bibliographic Details
Main Authors: Gustavo Bravo Ruiz, Michele Tinti, Melanie Ridgway, David Horn
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mSphere
Subjects:
Trypanosoma brucei
mRNA binding
proteomics
RNAi
Online Access:https://journals.asm.org/doi/10.1128/msphere.00069-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00069-22

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