Targeting of PDGF-C/NRP-1 autocrine loop as a new strategy for counteracting the invasiveness of melanoma resistant to braf inhibitors

Targeting of PDGF-C/NRP-1 autocrine loop as a new strategy for counteracting the invasiveness of melanoma resistant to braf inhibitors

Melanoma resistance to BRAF inhibitors (BRAFi) is often accompanied by a switch from a proliferative to an invasive phenotype. Therefore, the identification of signaling molecules involved in the development of metastatic properties by resistant melanoma cells is of primary importance. We have previ...

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Bibliographic Details
Main Authors: Federica Ruffini, Claudia Ceci, Maria Grazia Atzori, Simona Caporali, Lauretta Levati, Laura Bonmassar, Gian Carlo Antonini Cappellini, Stefania D’Atri, Grazia Graziani, Pedro Miguel Lacal
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Pharmacological Research
Subjects:
Melanoma
BRAF inhibitors
Neuropilin-1
PDGF-C
Dabrafenib
Extracellular matrix invasion
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182300138X

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http://www.sciencedirect.com/science/article/pii/S104366182300138X

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