TPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels

TPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels

Abstract To understand the role of intracellular zinc ion (Zn2+) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity resulting from the generation of excessive neurotoxic amyloid-β (Aβ) peptides, this study aimed to investigate whether N, N, N′, N′-tetrakis (...

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Bibliographic Details
Main Authors: Wen-bo Chen, Yu-xiang Wang, Hong-gang Wang, Di An, Dan Sun, Pan Li, Tao Zhang, Wan-ge Lu, Yan-qiang Liu
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Brain
Subjects:
TPEN
Aβ25–35
Zinc ions
Channel currents
Voltage-gated sodium channels
Voltage-gated potassium channels
Online Access:https://doi.org/10.1186/s13041-021-00837-z

Internet

https://doi.org/10.1186/s13041-021-00837-z

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