Globospiramine from <i>Voacanga globosa</i> Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations

Globospiramine from <i>Voacanga globosa</i> Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations

Bisindole alkaloids are a source of inspiration for the design and discovery of new-generation anticancer agents. In this study, we investigated the cytotoxic and antiproliferative activities of three spirobisindole alkaloids from the traditional anticancer Philippine medicinal plant <i>Voacan...

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Bibliographic Details
Main Authors: Joe Anthony H. Manzano, Elian Angelo Abellanosa, Jose Paolo Aguilar, Simone Brogi, Chia-Hung Yen, Allan Patrick G. Macabeo, Nicanor Austriaco
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
<i>Voacanga globosa</i>
globospiramine
spirobisindole alkaloid
cytotoxicity
antiproliferative
apoptosis
Online Access:https://www.mdpi.com/2073-4409/13/9/772

Internet

https://www.mdpi.com/2073-4409/13/9/772

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