EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia

EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia

Abstract The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the expression of IL3Rα (CD123) on B-ALL cell membranes. Interleukin 3 (IL-3) supp...

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Bibliographic Details
Main Authors: Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu, Jinsong Yan
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
EP300-ZNF384
IL3RA
IL-3
B-cell acute lymphoblastic leukemia
Leukemogenesis
Online Access:https://doi.org/10.1186/s12964-024-01596-9

Internet

https://doi.org/10.1186/s12964-024-01596-9

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