Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility to Fluconazole in <italic toggle="yes">Saccharomyces cerevisiae</italic> and <italic toggle="yes">Candida</italic> Species

Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility to Fluconazole in <italic toggle="yes">Saccharomyces cerevisiae</italic> and <italic toggle="yes">Candida</italic> Species

ABSTRACT MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitochondria. In this study, we identified MGE1 as a multicopy suppressor of susceptibility to the antifungal fluconazole in the model yeast Saccharomyces cerevisiae. We demonstrate that this phen...

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Bibliographic Details
Main Authors: Liesbeth Demuyser, Erwin Swinnen, Alessandro Fiori, Beatriz Herrera-Malaver, Kevin Verstrepen, Patrick Van Dijck
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Candida albicans
Candida glabrata
Fe-S cluster
Mge1
Saccharomyces cerevisiae
antifungal susceptibility
Online Access:https://journals.asm.org/doi/10.1128/mBio.00201-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00201-17

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