Exosomes Secreted by Adipose-Derived Stem Cells Following FK506 Stimulation Reduce Autophagy of Macrophages in Spine after Nerve Crush Injury

Exosomes Secreted by Adipose-Derived Stem Cells Following FK506 Stimulation Reduce Autophagy of Macrophages in Spine after Nerve Crush Injury

Macrophages emerge in the milieu around innervated neurons after nerve injuries. Following nerve injury, autophagy is induced in macrophages and affects the regulation of inflammatory responses. It is closely linked to neuroinflammation, while the immunosuppressive drug tacrolimus (FK506) enhances n...

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Bibliographic Details
Main Authors: Pao-Jen Kuo, Cheng-Shyuan Rau, Shao-Chun Wu, Chia-Wei Lin, Lien-Hung Huang, Tsu-Hsiang Lu, Yi-Chan Wu, Chia-Jung Wu, Chia-Wen Tsai, Ching-Hua Hsieh
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
sciatic nerve crush injury
exosome
adipose-derived stem cells (ADSC)
tacrolimus (FK506)
proteomic analysis
Online Access:https://www.mdpi.com/1422-0067/22/17/9628

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https://www.mdpi.com/1422-0067/22/17/9628

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