Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

The inheritance of variants that lead to coding changes in, or the mis-expression of, genes critical to pancreatic beta cell function can lead to alterations in insulin secretion and increase the risk of both type 1 and type 2 diabetes. Recently developed clustered regularly interspaced short palind...

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Bibliographic Details
Main Authors: Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
genome editing
beta cell
genome-wide association studies
maturity onset of diabetes of the young
stem cells
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.576632/full

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https://www.frontiersin.org/article/10.3389/fendo.2020.576632/full

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