A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development

Multiple genetic factors related to autism spectrum disorder (ASD) have been identified, but the biological mechanisms remain obscure. Timothy syndrome (TS), associated with syndromic ASD, is caused by a gain‐of‐function mutation, G406R, in the pore‐forming subunit of L‐type Ca2+ channels, Cav1.2. I...

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Bibliographic Details
Main Authors: Shin‐ichiro Horigane, Yukihiro Ozawa, Jun Zhang, Hiroe Todoroki, Pan Miao, Asahi Haijima, Yuchio Yanagawa, Shuhei Ueda, Shigeo Nakamura, Masaki Kakeyama, Sayaka Takemoto‐Kimura
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:FEBS Open Bio
Subjects:
autism spectrum disorder
IntelliCage
L‐type Ca2+ channels
neural circuit formation
social competitive dominance
Timothy syndrome
Online Access:https://doi.org/10.1002/2211-5463.12924

Internet

https://doi.org/10.1002/2211-5463.12924

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