Partial genome content within rAAVs impacts performance in a cell assay-dependent manner

Partial genome content within rAAVs impacts performance in a cell assay-dependent manner

Recombinant adeno-associated viruses (rAAVs) deliver DNA to numerous cell types. However, packaging of partial genomes into the rAAV capsid is of concern. Although empty rAAV capsids are studied, there is little information regarding the impact of partial DNA content on rAAV performance in controlle...

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Bibliographic Details
Main Authors: Bryan Troxell, Sarah L. Jaslow, I-Wei Tsai, Chelsea Sullivan, Benjamin E. Draper, Martin F. Jarrold, Kate Lindsey, Levi Blue
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CD-MS
SEC-MALS
live-cell imaging
transduction
NGS
ddPCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001092

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http://www.sciencedirect.com/science/article/pii/S2329050123001092

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