Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity...

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Bibliographic Details
Main Authors: Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J.I. Blackford, Laura Abelleira-Hervas, Robert D. Sampson, Ian O. Shum, Matthew J. Branch, Peter J. Gardner, Jane C. Sowden, James W.B. Bainbridge, Alexander J. Smith, Emma L. West, Rachael A. Pearson, Robin R. Ali
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Stem Cell Reports
Subjects:
stem cells
photoreceptor
differentiation
cone photoreceptors
retina and transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303326

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http://www.sciencedirect.com/science/article/pii/S2213671117303326

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