Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency

Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency

AimsThe risk of cardiovascular events in patients with Rheumatoid Arthritis (RA) is disproportionately heightened as a result of systemic inflammation. The relative effect of autoimmune-associated citrullination on the structure and thrombotic potential of fibrin(ogen) remains unknown. We therefore...

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Bibliographic Details
Main Authors: Johannes A. Bezuidenhout, Chantelle Venter, Timothy J. Roberts, Gareth Tarr, Douglas B. Kell, Etheresia Pretorius
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibrinogen
coagulation
citrullination
cardiovascular risk
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.577523/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.577523/full

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