Non-drug efflux function of ABCC5 promotes enzalutamide resistance in castration-resistant prostate cancer via upregulation of P65/AR-V7

Non-drug efflux function of ABCC5 promotes enzalutamide resistance in castration-resistant prostate cancer via upregulation of P65/AR-V7

Abstract Drug resistance is responsible for castration-resistant prostate cancer (CRPC)-associated mortality. While ATP binding cassette subfamily C member 5 (ABCC5) has been reported to regulate multiple drug resistance, its drug-efflux function may not be the main reason underlying resistance to e...

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Bibliographic Details
Main Authors: Haojie Chen, Jia Luo, Shaojun Chen, Bowen Shi, Xiaocui Zheng, Haiying Ji, Xiaoqian Zhang, Yujia Yin, Kun Du, Jie Ding, Yongjiang Yu
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00951-4

Internet

https://doi.org/10.1038/s41420-022-00951-4

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