Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders

Development of sex- and genotype-specific behavioral phenotypes in a Shank3 mouse model for neurodevelopmental disorders

Individuals with a SHANK3-related neurodevelopmental disorder, also termed Phelan-McDermid syndrome or abbreviated as PMS, exhibit significant global developmental delay, language impairment, and muscular hypotonia. Also common are repetitive behaviors and altered social interactions, in line with a...

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Bibliographic Details
Main Authors: Helen Friedericke Bauer, Jan Philipp Delling, Jürgen Bockmann, Tobias M. Boeckers, Michael Schön
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Phelan-McDermid syndrome
Shank3
behavior
autism spectrum disorders
mouse model
muscular hypotonia
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1051175/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1051175/full

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