VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway

Abstract Clear cell renal cell carcinomas (ccRCC) reprogram carbon metabolism responses to hypoxia, thereby promoting utilization of glutamine. Recently, sirtuin 4 (SIRT4), a novel molecular has turned out to be related to alternating glutamine metabolism and modulating the tumor microenvironment. H...

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Bibliographic Details
Main Authors: Ying Tong, Jinyan Kai, Shuo Wang, Yiwen Yu, Suhong Xie, Hui Zheng, Yanchun Wang, Yixuan Liu, Keyu Zhu, Xiaolin Guan, Lin Guo, Renquan Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03901-7

Internet

https://doi.org/10.1038/s41419-021-03901-7

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