Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis

Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis

Idiopathic pulmonary fibrosis (IPF), a severe and deadly form of lung fibrosis, is widely regarded as a disease of aging. We previously demonstrated that aged mice with persistent lung fibrosis and IPF lung myofibroblasts exhibit deficient Nrf2-mediated antioxidant responses. Tecfidera is an orally...

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Bibliographic Details
Main Authors: Kosuke Kato, Ioannis Papageorgiou, Yoon-Joo Shin, Jennifer M. Kleinhenz, Sunny Palumbo, Seongmin Hahn, Joseph D. Irish, Skye P. Rounseville, Kenneth S. Knox, Louise Hecker
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
idiopathic pulmonary fibrosis
dimethyl fumarate
Nrf2
aging
antioxidant
reactive oxygen species
Online Access:https://www.mdpi.com/2076-3921/11/3/492

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https://www.mdpi.com/2076-3921/11/3/492

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