Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway

Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway

Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads. By developing JAKs based affinity ultrafiltration method coupled with LC/Q-TOF-MS in order to discover selective JAKs i...

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Bibliographic Details
Main Authors: Yong-Qiang Tian, Dai Hu, Yong-Li Zhang, Jian Zou, Gui-Lin Chen, Ming-Quan Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Chemistry
Subjects:
Janus kinases inhibitors
total quaternary alkaloids (QAs)
Zanthoxylum simulans
gastric cancer (AGS)
anti-proliferative activity
estrogen receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.922110/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.922110/full

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