ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effective therapeutics do not yet exist. Transgenic rodent models based on over-expression of mutant SOD1 ha...

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Bibliographic Details
Main Authors: Erin J. McAllum, Blaine R. Roberts, James L. Hickey, Theresa N. Dang, Alexandra Grubman, Paul S. Donnelly, Jeffrey R. Liddell, Anthony R. White, Peter J. Crouch
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Copper/zinc-superoxide dismutase (SOD1)
Therapeutic
Copper
Zinc
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000583

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http://www.sciencedirect.com/science/article/pii/S0969996115000583

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