ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

ZnII(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effective therapeutics do not yet exist. Transgenic rodent models based on over-expression of mutant SOD1 ha...

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Bibliographic Details
Main Authors:	Erin J. McAllum, Blaine R. Roberts, James L. Hickey, Theresa N. Dang, Alexandra Grubman, Paul S. Donnelly, Jeffrey R. Liddell, Anthony R. White, Peter J. Crouch
Format:	Article
Language:	English
Published:	Elsevier 2015-09-01
Series:	Neurobiology of Disease
Subjects:	Amyotrophic lateral sclerosis (ALS) Copper/zinc-superoxide dismutase (SOD1) Therapeutic Copper Zinc Mouse model
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996115000583

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