Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation

Summary: Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival. We investigate how these functions c...

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Bibliographic Details
Main Authors: Jieqiong Zhang, Joshua D. Webster, Debra L. Dugger, Tatiana Goncharov, Merone Roose-Girma, Jeffrey Hung, Youngsu C. Kwon, Domagoj Vucic, Kim Newton, Vishva M. Dixit
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306011

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http://www.sciencedirect.com/science/article/pii/S2211124719306011

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