Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα

Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα

Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural simil...

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Bibliographic Details
Main Authors: Ilija N. Cvijetić, Barbara Herlah, Aleksandar Marinković, Andrej Perdih, Snežana K. Bjelogrlić
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
thiocarbohydrazones
human DNA topoisomerase IIα
catalytic inhibitors
dynophores
molecular dynamics
cancer research
Online Access:https://www.mdpi.com/1424-8247/16/3/341

Internet

https://www.mdpi.com/1424-8247/16/3/341

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