Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice

Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice

Chronic pain burdens patients and healthcare systems worldwide. Pain control remains urgently required. IL-17 (interleukin-17)-mediated neuroinflammation is of unique importance in spinal nociceptive transduction in pathological pain development. Recently, resolvin D2 (RvD2), as a bioactive, special...

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Bibliographic Details
Main Authors: Jun Pang, Pengfei Xin, Ying Kong, Zhe Wang, Xiaopeng Wang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Brain Sciences
Subjects:
RvD2
neuropathic pain
bone cancer pain
IL-17
CXCL1
astrocyte activation
Online Access:https://www.mdpi.com/2076-3425/13/1/152

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https://www.mdpi.com/2076-3425/13/1/152

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