In situ transduction of cells in human corneal limbus using adeno-associated viruses: an ex vivo study

Abstract This study aimed to evaluate the efficacy of in situ adeno-associated virus (AAV)-mediated gene delivery into the human corneal limbal region via targeted sub-limbal injection technique. Human cadaveric corneal tissues were fixed on an artificial anterior chamber. Feasibility of sub-limbal...

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Bibliographic Details
Main Authors: Hyeck-Soo Son, Albert S. Jun, James W. Foster, Wei Wang, Yassine Daoud, Gerd U. Auffarth, Madhuparna Roy
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26926-0