Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway To Promote HIV-1 Infection and Reactivation

ABSTRACT Multiple cellular metabolic pathways are altered by HIV-1 infection, with an impact on immune activation, inflammation, and acquisition of non-AIDS comorbid diseases. The dysfunction of tryptophan (Trp) metabolism has been observed clinically in association with accelerated HIV-1 pathogenes...

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Bibliographic Details
Main Authors: Yan-Heng Zhou, Li Sun, Jun Chen, Wei-Wei Sun, Li Ma, Yang Han, Xia Jin, Qing-Xia Zhao, Taisheng Li, Hongzhou Lu, Xiu Qiu, Jian-Hua Wang
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mBio
Subjects:
HIV-1
aryl hydrocarbon receptor
tryptophan metabolite
transcription
Online Access:https://journals.asm.org/doi/10.1128/mBio.02591-19

Internet

https://journals.asm.org/doi/10.1128/mBio.02591-19

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