Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease

Mechanotransduction Impairment in Primary Fibroblast Model of Krabbe Disease

Krabbe disease (KD) is a genetic disorder caused by the absence of the galactosylceramidase (GALC) functional enzyme. No cure is currently available. Here, we investigate the mechanotransduction process in primary fibroblasts collected from the twitcher mouse, a natural KD murine model. Thanks to me...

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Bibliographic Details
Main Authors: Roberta Mezzena, Ambra Del Grosso, Roberto Maria Pellegrino, Husam B. R. Alabed, Carla Emiliani, Ilaria Tonazzini, Marco Cecchini
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
mechanotransduction
Krabbe disease
focal adhesions
migration
autophagy
Online Access:https://www.mdpi.com/2227-9059/11/3/927

Internet

https://www.mdpi.com/2227-9059/11/3/927

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