The pharmacokinetic and pharmacodynamic properties and short-term outcome of a novel once-weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency

The pharmacokinetic and pharmacodynamic properties and short-term outcome of a novel once-weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency

ObjectivesTo investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of Y-shape branched PEGylated recombinant human growth hormone (YPEG-rhGH) and evaluate its short-term efficacy and safety in children with growth hormone deficiency (GHD).MethodsA total of 43 children with GHD from 12 site...

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Bibliographic Details
Main Authors: Yan Liang, Cai Zhang, Haiyan Wei, Hongwei Du, Gaixiu Zhang, Yu Yang, Hua Zhang, Haihong Gong, Pin Li, Fuying Song, Zhuangjian Xu, Ruoyi He, Weidong Zhou, Heng Zheng, Li Sun, Xiaoping Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
long-acting growth hormone
Y-shape branched PEGylation
growth hormone deficiency
prepubertal children
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.922304/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.922304/full

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