Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

ABSTRACTBK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and cytotoxic T-cells, respectively. Our...

Full description

Bibliographic Details
Main Authors: Janani Durairaj, Océane M. Follonier, Karoline Leuzinger, Leila T. Alexander, Maud Wilhelm, Joana Pereira, Caroline A. Hillenbrand, Fabian H. Weissbach, Torsten Schwede, Hans H. Hirsch
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mSphere
Subjects:
polyomavirus
BK virus
serotype
genotype
variant
mutant
Online Access:https://journals.asm.org/doi/10.1128/msphere.00799-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00799-23

Similar Items