Anticoagulant Oligonucleotide–Peptide Conjugates: Identification of Thrombin Aptamer Conjugates with Improved Characteristics

Anticoagulant Oligonucleotide–Peptide Conjugates: Identification of Thrombin Aptamer Conjugates with Improved Characteristics

Oligonucleotide–peptide conjugates (OPCs) are a promising class of biologically active compounds with proven potential for improving nucleic acid therapeutics. OPCs are commonly recognized as an efficient instrument to enhance the cellular delivery of therapeutic nucleic acids. In addition to this a...

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Bibliographic Details
Main Authors: Vladimir B. Tsvetkov, Irina V. Varizhuk, Nikolay N. Kurochkin, Sergei A. Surzhikov, Igor P. Smirnov, Andrey A. Stomakhin, Natalia A. Kolganova, Edward N. Timofeev
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
thrombin binding aptamer
G-quadruplex
oligonucleotide–peptide conjugate
circular dichroism
anticoagulant activity
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/7/3820

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https://www.mdpi.com/1422-0067/23/7/3820

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