A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats

A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats

Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter (DAT) are widely used for...

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Bibliographic Details
Main Authors: Agnieszka Nikiforuk, Predrag Kalaba, Marija Ilic, Volker Korz, Vladimir Dragačević, Judith Wackerlig, Thierry Langer, Harald Höger, Joanna Golebiowska, Piotr Popik, Gert Lubec
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
cognitive flexibility
novel DAT inhibitors
cognitive enhancement
diminished side effects
impulsivity
Online Access:http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00222/full

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http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00222/full

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