Insights into the Possible Molecular Mechanisms of Resistance to PARP Inhibitors
PARP1 enzyme plays an important role in DNA damage recognition and signalling. PARP inhibitors are approved in breast, ovarian, pancreatic, and prostate cancers harbouring a pathogenic variant in <i>BRCA1</i> or <i>BRCA2</i>, where PARP1 inhibition results mainly in synthetic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/11/2804 |