hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat A. fumigatus infections, but their u...

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Bibliographic Details
Main Authors: Ana C. O. Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Aspergillus fumigatus
triazole drug resistance
hmg1
hapE
CCAAT box binding complex
Online Access:https://journals.asm.org/doi/10.1128/spectrum.05188-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.05188-22

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