Oncobox Bioinformatical Platform for Selecting Potentially Effective Combinations of Target Cancer Drugs Using High-Throughput Gene Expression Data

Oncobox Bioinformatical Platform for Selecting Potentially Effective Combinations of Target Cancer Drugs Using High-Throughput Gene Expression Data

Sequential courses of anticancer target therapy lead to selection of drug-resistant cells, which results in continuous decrease of clinical response. Here we present a new approach for predicting effective combinations of target drugs, which act in a synergistic manner. Synergistic combinations of d...

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Bibliographic Details
Main Authors: Maxim Sorokin, Roman Kholodenko, Maria Suntsova, Galina Malakhova, Andrew Garazha, Irina Kholodenko, Elena Poddubskaya, Dmitriy Lantsov, Ivan Stilidi, Petr Arhiri, Andreyan Osipov, Anton Buzdin
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
target therapeutics
tyrosine kinase inhibitors
rapalogues
cancer
synergistic combinations
drug resistant tumor cells
bioinformatics
molecular pathways
Online Access:http://www.mdpi.com/2072-6694/10/10/365

Internet

http://www.mdpi.com/2072-6694/10/10/365

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