Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling

Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling

Abstract Background The aim of this study was to investigate the protective effect and mechanism of oridonin in an in vitro lipopolysaccharide (LPS)-induced human periodontal ligament stem cells (hPDLSCs) model of periodontitis. Methods Primary hPDLSCs were isolated and cultured, and then the expres...

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Bibliographic Details
Main Authors: Junhao Jiang, Nong Zhang, Haibo Song, Ya Yang, Juan Li, Xiaoli Hu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Oral Health
Subjects:
Oridonin
Endoplasmic reticulum (ER) stress
NF-κB/NLRP3 inflammasome
Human periodontal ligament stem cells (hPDLSCs)
Osteogenic potential
Online Access:https://doi.org/10.1186/s12903-023-02827-0

Internet

https://doi.org/10.1186/s12903-023-02827-0

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