Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an attractive prospect of the cell-replacement therapy for Parkinson’s disease (PD). However, it is unclear whether repressing polypyrimidine tract binding protein 1 (PTBP1) could efficiently convert astrocyte to DAns in...

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Bibliographic Details
Main Authors: Weizhao Chen, Qiongping Zheng, Qiaoying Huang, Shanshan Ma, Mingtao Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
PTBP1
astrocyte-to-neuron conversion
lineage reprogramming
Parkinson's disease
6-OHDA model
astrocyte
Online Access:https://elifesciences.org/articles/75636

Internet

https://elifesciences.org/articles/75636

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