Haemonchus contortus HcL6 promoted the Th9 immune response in goat PBMCs by activating the STAT6/PU.1/NF-κB pathway

Haemonchus contortus HcL6 promoted the Th9 immune response in goat PBMCs by activating the STAT6/PU.1/NF-κB pathway

Abstract Th9 cells play a crucial role in parasite immunity. The development of Th9 cells is facilitated by several cytokines. Key transcription factors, such as STAT6, STAT5, and PU.1, are known to enhance IL-9 expression during the Th9 immune response. NF-κB-mediated transduction pathways particip...

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Bibliographic Details
Main Authors: Meng Liang, Yang Zhang, Mingyue Wang, Zhaohai Wen, Cheng Chen, Yongqian Bu, Mingmin Lu, Xiaokai Song, Lixin Xu, Xiangrui Li, Ruofeng Yan
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Veterinary Research
Subjects:
Haemonchus contortus
HcL6
goat
Th9 immunity
STAT6
PU.1
Online Access:https://doi.org/10.1186/s13567-023-01214-5

Internet

https://doi.org/10.1186/s13567-023-01214-5

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