Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity

Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity

Objective: Insulin resistance causes type 2 diabetes mellitus and hyperglycemia due to excessive hepatic glucose production and inadequate peripheral glucose uptake. Our objectives were to test the hypothesis that the proposed CREB/CRTC2 inhibitor salt inducible kinase 1 (SIK1) contributes to whole...

Full description

Bibliographic Details
Main Authors: Mark Nixon, Randi Stewart-Fitzgibbon, Jingqi Fu, Dmitry Akhmedov, Kavitha Rajendran, Maria G. Mendoza-Rodriguez, Yisel A. Rivera-Molina, Micah Gibson, Eric D. Berglund, Nicholas J. Justice, Rebecca Berdeaux
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Metabolism
Subjects:
SIK1
Salt inducible kinase
CRTC
Gluconeogenesis
Insulin resistance
CREB
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815001994

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815001994

Similar Items