Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68.

Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68.

All gammaherpesviruses express homologues of antiapoptotic B-cell lymphoma-2 (BCL-2) to counter the clearance of infected cells by host antiviral defense machineries. To gain insights into the action mechanisms of these viral BCL-2 proteins, we carried out structural and biochemical analyses on the...

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Bibliographic Details
Main Authors: Bonsu Ku, Jae-Sung Woo, Chengyu Liang, Kwang-Hoon Lee, Hyang-Suk Hong, Xiaofei E, Key-Sun Kim, Jae U Jung, Byung-Ha Oh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2222952?pdf=render

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http://europepmc.org/articles/PMC2222952?pdf=render

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