Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization and aggregation of which are key pathological fea...

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Bibliographic Details
Main Authors: Tongcui Jiang, Emily Handley, Mariana Brizuela, Edgar Dawkins, Katherine E. A. Lewis, Rosemary M. Clark, Tracey C. Dickson, Catherine A. Blizzard
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Disease Models & Mechanisms
Subjects:
TDP-43
Synapse
Dendrite spine
AMPA
Excitability
Online Access:http://dmm.biologists.org/content/12/5/dmm038109

Internet

http://dmm.biologists.org/content/12/5/dmm038109

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