Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation

Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation

Cyclosporine-A-loaded PLGA implants were developed intended for ocular route. Implants were prepared using solvent extraction/evaporation technique followed by casting of the cake into rods in a heated surface. XRD patterns showed that cyclosporine-A was completely incorporated into PLGA. FTIR and D...

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Bibliographic Details
Main Authors: Juliana Barbosa Saliba, Armando da Silva-Cunha Junior, Gisele Rodrigues da Silva, Maria Irene Yoshida, Alexandra Ancelmo Piscitelli Mansur, Herman Sander Mansur
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
cyclosporine-A
poly(D,L-lactide-co-glycolide) (PLGA)
biodegradable intraocular implant
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400013&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400013&lng=en&tlng=en

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