Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine

Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine

Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Selective TAAR1 full and partial agonists ex...

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Bibliographic Details
Main Authors: Michael D. Schwartz, Jeremiah B. Palmerston, Diana L. Lee, Marius C. Hoener, Thomas S. Kilduff
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
TAAR1
sleep
arousal
psychostimulants
caffeine
dopamine
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00035/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00035/full

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