The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis. Here, we show that Tie1 does not function independent...

Full description

Bibliographic Details
Main Authors: Soniya Savant, Silvia La Porta, Annika Budnik, Katrin Busch, Junhao Hu, Nathalie Tisch, Claudia Korn, Aida Freire Valls, Andrew V. Benest, Dorothee Terhardt, Xianghu Qu, Ralf H. Adams, H. Scott Baldwin, Carmen Ruiz de Almodóvar, Hans-Reimer Rodewald, Hellmut G. Augustin
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715008955

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715008955

Similar Items