Antifibrotic therapy to normalize the tumor microenvironment

Antifibrotic therapy to normalize the tumor microenvironment

Abstract Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant fibrotic tumor microenvironment (TME) is associated with poor outcome of treatment. It has been hypothesize...

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Bibliographic Details
Main Authors: Anette Hauge, Einar K. Rofstad
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Translational Medicine
Subjects:
Antifibrotic therapy
Cancer-associated fibroblasts
Extracellular matrix
Tumor microenvironment
Profibrotic signaling pathways
Targeted treatments
Online Access:http://link.springer.com/article/10.1186/s12967-020-02376-y

Internet

http://link.springer.com/article/10.1186/s12967-020-02376-y

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