Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells

Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells

Shear stress exerted by the blood stream modulates endothelial functions through altering gene expression. KLF2 and KLF4, the mechanosensitive transcription factors, are promoted by laminar flow to maintain endothelial homeostasis. However, how the expression of KLF2/4 is regulated by shear stress i...

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Bibliographic Details
Main Authors: Qi Zheng, Yonggang Zou, Peng Teng, Zhenghua Chen, Yuefeng Wu, Xiaoyi Dai, Xiya Li, Zonghao Hu, Shengjun Wu, Yanhua Xu, Weiguo Zou, Hai Song, Liang Ma
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
PIEZO1
KLF2/4
endothelial cell
mechanosensitive transcription factor
shear stress
signal transduction
Online Access:https://www.mdpi.com/2073-4409/11/14/2191

Internet

https://www.mdpi.com/2073-4409/11/14/2191

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