Single‐cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases

Single‐cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases

Abstract Leptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single‐cell level. Based on the 10× genomics single‐cell RN...

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Bibliographic Details
Main Authors: Haoyu Ruan, Zhe Wang, Ziwei Sun, Jia Wei, Lei Zhang, Huanyu Ju, Ting Wang, Chao Zhang, Ming Guan, Shiyang Pan
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Clinical and Translational Medicine
Subjects:
Cerebrospinal fluid
circulating tumour cells
gene regulatory networks
leptomeningeal metastases
tumour microenvironment
Online Access:https://doi.org/10.1002/ctm2.885

Internet

https://doi.org/10.1002/ctm2.885

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