Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinction, whereas inhibiting monoacylglycerol lipase (M...

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Bibliographic Details
Main Authors: William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
2-arachidonoylglycerol
anandamide
anxiety
cannabinoid
fatty acid amide hydrolase
immediate extinction deficit
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1082760/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1082760/full

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