Identification of Molecular Mechanisms Responsible for the MMP-9-1562C/T Dependent Differential Regulation of Matrix Metalloproteinase-9 Expression in Human Neuron-like Cells

Identification of Molecular Mechanisms Responsible for the MMP-9-1562C/T Dependent Differential Regulation of Matrix Metalloproteinase-9 Expression in Human Neuron-like Cells

The MMP-9-1562C/T polymorphism exerts an impact on the occurrence and progression of numerous disorders affecting the central nervous system. Using luciferase assays and Q-RT-PCR technique, we have discovered a distinct allele-specific influence of the MMP-9-1562C/T polymorphism on the <i>MMP-...

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Bibliographic Details
Main Authors: Sylwia Pabian-Jewuła, Magdalena Ambrożek-Latecka, Aneta Brągiel-Pieczonka, Klaudia Nowicka, Marcin Rylski
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Genes
Subjects:
<i>MMP-9</i>
MMP-9-1562C/T polymorphism
transcriptional regulation
brain
human neurons
Online Access:https://www.mdpi.com/2073-4425/14/11/2028

Internet

https://www.mdpi.com/2073-4425/14/11/2028

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