Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Abstract Background “Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is underexplored in autosomal dominant AD (ADAD), in which AD...

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Bibliographic Details
Main Authors: Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Molecular Neurodegeneration
Subjects:
Brain aging
Alzheimer disease
Structural MRI
Machine learning
Online Access:https://doi.org/10.1186/s13024-023-00688-3

Internet

https://doi.org/10.1186/s13024-023-00688-3

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