Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates
Abstract Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mH...
Hoofdauteurs: | , , , , , , , , , , |
---|---|
Formaat: | Artikel |
Taal: | English |
Gepubliceerd in: |
SpringerOpen
2024-12-01
|
Reeks: | EJNMMI Research |
Onderwerpen: | |
Online toegang: | https://doi.org/10.1186/s13550-024-01188-1 |