Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates
Abstract Background Huntington’s disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mH...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2024-12-01
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Series: | EJNMMI Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13550-024-01188-1 |